The “metabolically healthy obese” and “metabolically-unhealthy normal-weight” phenotypes: opposite sides of the same coin?

Faidon Magkos is Associate Professor at the Department of Nutrition, Exercise and Sports at the University of Copenhagen.

It has become apparent in recent years that excess total body weight and fat do not necessarily impair metabolic function and increase risk for cardiometabolic disease; and vice versa, absence of excess weight and fat do not necessarily entail low risk. A subset (~30%) of people with obesity do not present with metabolic abnormalities such as hyperglycemia, hyperinsulinemia, and dyslipidemia, or hypertension (“metabolically healthy obese”); whereas a subset (~20%) of people with normal body weight do present with these metabolic abnormalities (“metabolically-unhealthy normal-weight”). Compared with BMI-matched control groups, metabolically healthy obese subjects have lower accumulation of fat in the liver, better physical fitness, and a tight coordination between the pancreas (insulin secretion) and skeletal muscle (insulin sensitivity) to maintain glucose homeostasis; whereas conversely, metabolically-unhealthy normal-weight subjects have more liver fat, inferior fitness, and dysregulated glucose homeostasis.

Foreleser: Faidon Magkos, the Department of Nutrition, Exercise and Sports, University of Copenhagen
Moderator: Simon Dankel
Tid: Torsdag 24. mars 2022 kl. 14.30-15.30
Sted: Aud. Glasblokkene, blokk 1  / Zoom

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