Daily Archives: Friday September 27th, 2019

Single cell studies, new technique established at K2

The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). This quote is from the presentation of “The Human Cell Atlas” in eLife. The Human Cell Atlas Consortium is an international collaborative project aimed at describing all types of human cells and linking this information with classical cell biology knowledge such as localization and morphology. The atlas will be openly available to all researchers. In June, The Chan Zuckerberg Initiative granted $ 68 million to 38 research groups around the world to study various organs and systems (like the immune system) in different populations using blood and organ specimens (organ donors, surgical tissue). In the next few years a host of information will be available to increase our understanding of normal physiology and pathology.

Some of the research groups at K2 have started using these methods, but now nine different groups at our faculty have pitched in money to buy the10X Genomics technology, making it easier to get started with single-cell studies. With 10x technology, up to 10,000 single cells can be studied in one experiment. The technique is based on the isolation of single cells in oil droplets together with a package of barcoded primers. In addition to RNA-seq 10x performs copy number profiling, ATAC sequencing at single cell resolution and long read genome- and exome sequencing (https://www.10xgenomics.com/). This enables one to extract information about the individual cell after bulk sequencing of the sample, and for example construct a tissue map where the cells are grouped according to properties. The technique opens up a wealth of opportunities to study disease processes at the single cell level and test out various treatments. A nearby example is cancer treatment and treatment responses to various tumor cells.

The 10X machine will be located on the Flow Cytometry Core Facility at K2. Those interested can contact the Core Facility for further information. I hope that many groups will seize the opportunity to use single cell techniques.

Good luck

Eystein Husebye

Seminarserie Senter for ernæring, onsdag 2. oktober

Senter for ernæring har gleden av å invitere til et nytt seminar i vår seminarrekke. Serien tar opp sentrale utfordringer innen ernæring og helse.

Tid: Onsdag 2. oktober kl. 14.30-15.30

Sted: Auditorium 2, BB-bygget, Jonas Lies vei 91

Computational Data Analytics on the Web for Better Food Decision

Speaker: Christoph Trattner 

Moderator: Gülen Arslan Lied

Christoph Trattner is an Associate Professor at the University of Bergen at the Information Science & Media Studies Department. Previously, he was an Asst. Prof. at MODUL University Vienna at the New Media Technology Department. He also founded and led the Social Computing department at the Know-Center, Austria’s research competence for data-driven business and big data analytics.

According to the World Health Organization around 80% of cases of heart disease, strokes and type 2 diabetes could be avoided if people were to implement a healthier diet. Computational data analytics approaches have been touted as a valuable asset in achieving the ambitious goal of understanding user behavior and being able to develop intelligent online systems, which can positively influence people’s food choices. In this talk, he will present his latest research on computational data analytics approaches to understand, predict and potentially change food decision making in an online context.

Det blir lett servering.



Immunology, stem cell treatment and cancer medicine

The Biomedical Network invites you to a seminar on Immunology, stem cell treatment and cancer medicine

Time: 16 October at 13.30

Venue: Bikuben, Haukeland University Hospital

Registration here.

The Biomedical Network is a collaboration initiative between Helse Bergen, UiB, Legemiddelindustriforeningen and VIS. The intention behind the network, which is supported by the Research Council of Norway, is to create a joint platform for innovation and project development across academic, public and private actors.

13:30 – 14:35 Åpning

Forskningsdirektør/Førsteamanuensis Eli Renate Grüner, Helse Bergen/UiB 

Autolog stamcellebehandling

Overlege/Professor Lars Bø, Helse Bergen/UiB

Immunologiske preparater

Arnt-Ove Hovden, Medical Affairs Lead & Medical Manager hos Boehringer Ingelheim

Immunterapi ved melanom

Overlege/Professor Oddbjørn Straume, Helse Bergen/UiB

Hvilke muligheter opplever farmasøytiske firma innenfor immunologisk terapi

Andrey Solokov, Medical Advisor hos AbbVie

14:35 – 15:05 Mingling og lett servering
15:05 – 15:50 Støtteordninger fra forskningsrådet

Spesialrådgiver Rigmor Fardal, Forskningsrådet

NorCRINs arbeide for å bedre forholdene for kliniske utprøvingsstudier

Overlege Camilla Tøndel, NorCRIN/Helse Bergen

Pasienterfaringer fra deltakelse i kliniske utprøvingsstudier

15:50 – 16:05 Pause
16:05 – 16:35 Precision Imaging in Gynecologic Cancer 

Overlege/Professor Ingfrid S. Haldorsen, UiB/Helse Bergen

Advanced medical visualization

Førsteamanuensis Noeska Smit, UiB


New name: Cathrine Ebbing

Cathrine Ebbing started working 1.9 2019 in a 50% position as associate professor at K2. I am a specialist in obstetrics and gynecology and have been working at the Women’s Clinic in Bergen since 1999. My specialty is fetal medicine and ultrasound. My research area is both clinical research in fetal and perinatal medicine, but also epidemiological research with data from the Medical Birth Register of Norway. I have been assigned the task of leading the research group “Pregnancy, fetal development and childbirth” under K2 in my position as 50% amanuensis. I am looking forward to that, and to teaching medicine students. She can be contacted on email: Cathrine.Ebbing@helse-bergen.no  Cathrine.Ebbing@molmed.uib.no




New name: Jan Anker

Jan Anker Jahnsen started working in a 20% position as associate professor in July 2019, with academic responsibility for FARM395, a course in pharmacotherapy for fifth year pharmacy students. The main employer is RELIS Vest, the medicines information and pharmacovigilance centre servicing the counties Hordaland, Rogaland and Sogn og Fjordane, which is situated on the 9th floor in the Laboratory-building (Laboratoriebygget). He is cand. pharm from The University of Copenhagen, has a PhD in pharmacology from UiB and will be affiliated with The Bergen Pharmacology & Pharmacy Research Group (G4).

You can get in touch with Jan Anker through e-mail: jan.anker.jahnsen@helse-bergen.no


New name: Elham Baghesta

Elham Baghesta started in a permanent 50% position as associate professor 01.09.19 at K2. She have worked at the women’s clinic since 2001 and still work 50% as a general consultant at KK. Her work and research is in obstetrics and on a daily basis she is working mostly with patients with pelvic floor injuries as a result of childbirth.

Email address: elham.baghestan@uib.no


New name: Maria Omsland

Maria Omsland Enrolled in a CCBIO Post Doc position at the research group headed by Prof. Bjørn Tore Gjertsen (The signaling-targeted therapy group). Omsland has a BSc in biomedical laboratory sciences and MSc and PhD in Medical Cell Biology which was completed in the same research group in 2017. She just returned from a 2-year long research stay as a visiting fellow at the National Institutes of Health (NIH) and enrolled in the new position at K2 20.08.2019. In her new Post Doc project, she will focus on cell-to-cell communication and signaling in the bone marrow compartment of chronic myeloid leukemia before and during treatment with tyrosine kinase inhibitors. The main methods will be the new imaging mass cytometer (IMC) and 2-photon microscopy of living organisms. E-mail: maria.omsland@uib.no




New publications

Here are recent publications with contributions from K2 based on last week’s search on PubMed (and optionally articles that have not been included in previous lists). This time the list includes in total 7 recent publications. The entries appear in the order they were received from NCBI. If you have publications that are not included in this or previous lists, please send the references to Hege F. Berg.

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