Boge Lauvsnes tildelt Sjögren’s Syndrome Foundation’s Outstanding Abstract Award. I sitt arbeid – Hippocampal Atrophy Is Associated with Anti-NR2 Antibodies in Patients with Systemic Lupus Erythematosus and Primary Sjogren’s Syndrome – har hun vist at en type av anti-NMDA reseptor antistoffer (anti-NR2 antistoffer) forårsaker atrofi av hjernestrukturen hippocampus hos mennesker med de immunologske sykdommene SLE og primært Sjögrens syndrom. Dette bekrefter dyreeksperimentelle studier som har vist at anti-NR2 antistoffer fører til neuronal død i hippocampus hos mus.
Både ved SLE og primært Sjögrens syndrom er slike antistoffer assosiert med kognitiv svikt, og kan utgjøre en generell mekanisme for cerebral affeksjon ved immunopatier.
Maria Boge Lauvsnes arbeider i Klinisk immunologisk forskningsgruppe ved Stavanger universitetssjukehus.As part of the annual meeting of American College of Rheumatology (ACR) in Boston, USA, PhD-Candidate/LIS-doctor Maria Boge Lauvsnes was awarded the Sjögren’s Syndrome Foundation’s Outstanding Abstract Award. Through her work – Hippocampal Atrophy Is Associated with Anti-NR2 Antibodies in Patients with Systemic Lupus Erythematosus and Primary Sjögren’s Syndrome – she has shown that a type of anti-NMDA receptor antibodies (anti-NR2 antibodies) cause atrophy of the brain structure hippocampus in humans with the immunological diseases SLE and primary Sjögren’s syndrome. This has been confirmed in animal models, which have revealed that anti-NR2 antibodies cause neuronal death of hippocampus in mice.
Such antibodies are associated with cognitive failure in both SLE and primary Sjögren’s syndrome, and they may constitute a general mechanism for cerebral affection with immunopathies.
Maria Boge Lauvsnes works for the Clinical Immunological Research Group at Stavanger University Hospital