{"id":12548,"date":"2017-08-09T12:08:52","date_gmt":"2017-08-09T11:08:52","guid":{"rendered":"http:\/\/k2info.w.uib.no\/?p=12548"},"modified":"2017-08-09T12:08:58","modified_gmt":"2017-08-09T11:08:58","slug":"congratulations-on-your-publication-in-jama","status":"publish","type":"post","link":"https:\/\/k2info.w.uib.no\/nb_no\/2017\/08\/09\/congratulations-on-your-publication-in-jama\/","title":{"rendered":"Congratulations on your publication in JAMA"},"content":{"rendered":"

[:no]\"alf_inge_larsen_og_eldar_soreide\"<\/a>NY INTERNASJONAL STUDIE VISER AT LENGRE NEDKJ\u00d8LING ETTER HJERTESTANS IKKE GIR SIKKER BEDRING AV PROGNOSEN<\/p>\n

Stavanger universitetssjukehus har som eneste norske sykehus deltatt i en europeisk hjertestansstudie som nylig ble publisert i Journal of the American Medical Association (JAMA). Selv om ikke studien viste at 48 timers nedkj\u00f8lingsperiode gav signifikant bedre resultat enn standard 24 timers nedkj\u00f8ling var der likevel en interessant forskjell i 6-m\u00e5neders overlevelse som kan indikere at en st\u00f8rre studie b\u00f8r gjennomf\u00f8res for \u00e5 avklare sp\u00f8rsm\u00e5let.<\/em><\/p>\n

I 2013 inngikk professor Eldar S\u00f8reide (K1) og professor Alf Ingen Larsen (K2), som ledere av henholdsvis akuttmedisinsk og kardiologisk forskningsgruppe ved SUS, en forskningsintensjonsavtale med Aarhus universitetssykehus. Et av resultatene er<\/p>\n

Targeted Temperature Management for 48 vs 24 Hours and Neurologic Outcome After Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial.
\n<\/a>Kirkegaard H, S\u00f8reide E, de Haas I, Pettil\u00e4 V, Taccone FS, Arus U, Storm C, Hassager C, Nielsen JF, S\u00f8rensen CA, Ilkj\u00e6r S, Jeppesen AN, Grejs AM, Duez CHV, Hjort J, Larsen AI, Toome V, Tiainen M, H\u00e4stbacka J, Laitio T, Skrifvars MB.
\nJAMA. 2017 Jul 25;318(4):341-350. doi: 10.1001\/jama.2017.8978.<\/p>\n

som nylig ble publisert i JAMA.<\/p>\n

Studien ble beh\u00f8rig kommentert i en lederartikkel av en av de fremste ekspertene p\u00e5 feltet, professor Cliffton Callaway fra Pittsburgh universitetet.<\/p>\n

Targeted Temperature Management After Cardiac Arrest: Finding the Right Dose for Critical Care Interventions.<\/a><\/p>\n

Callaway CW. JAMA. 2017 Jul 25;318(4):334-336. doi: 10.1001\/jama.2017.8977.<\/p>\n

Callaway poengterte at selv om studien ikke klarte \u00e5 vise en statistisk signifikant 15% absolutt forskjell i overlevelse mellom gruppene, tydet resultatene p\u00e5 at der kunne foreligge en mindre men likevel interessant forskjell i fav\u00f8r av lengre nedkj\u00f8lings-periode. Dette vil kun en mye st\u00f8rre studie kunne bekrefte eller avkrefte. Videre ble studien ber\u00f8mmet for b\u00e5de god datakvalitet og god oppf\u00f8lging av pasientene.\u00a0 Overlevelsen i begge studiegruppene var ogs\u00e5 mye h\u00f8yere enn den som er rapportert i tidligere liknende studier. Dette kan skyldes flere forhold, ikke minst at b\u00e5de den prehospitale og hospitale behandlingen generelt er blitt bedre over \u00e5r.<\/p>\n

De to norske medforfattere av studien \u00f8nsker \u00e5 takke alt involvert helsepersonell generelt og familiene og pasientene som sa ja til \u00e5 delta spesielt. De synes denne publikasjonen illustrerer mulighetene og betydningen av samarbeid mellom forskningsgrupper og mellom institusjoner i flere land. P\u00e5 den m\u00e5ten h\u00e5per de publikasjonen kan tjene til inspirasjon for yngre kolleger.[:en]\"alf_inge_larsen_og_eldar_soreide\"<\/a>NEW INTERNATIONAL STUDY SHOWS LONGER COOLING AFTER HEART STAY DOES NOT GUARANTEE INTEREST OF PROGNOSEN<\/span><\/p>\n

Stavanger University Hospital has, as the only Norwegian hospital, participated in a European cardiac arrest study recently published in the Journal of the American Medical Association (JAMA). Although the study did not show that the 48 hour cooling period yielded significantly better results than the standard 24 hour cooling, there was still an interesting difference in 6-month survival that could indicate that a major study should be conducted to clarify the question.<\/span><\/em><\/p>\n

In 2013, Professor Eldar S\u00f8reide (K1) and Professor Alf Ingen Larsen (K2), as leaders of the Emergency Medical and Cardiological Research Group at SUS, entered into a research agreement with Aarhus University Hospital. One of the results is<\/span><\/p>\n

Targeted Temperature Management for 48 vs 24 Hours and Neurologic Outcome After Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial.
\n<\/a>Kirkegaard H, S\u00f8reide E, de Haas I, Pettil\u00e4 V, Taccone FS, Arus U, Storm C, Hassager C, Nielsen JF, S\u00f8rensen CA, Ilkj\u00e6r S, Jeppesen AN, Grejs AM, Duez CHV, Hjort J, Larsen AI, Toome V, Tiainen M, H\u00e4stbacka J, Laitio T, Skrifvars MB.
\nJAMA. 2017 Jul 25;318(4):341-350. doi: 10.1001\/jama.2017.8978.<\/p>\n

Wchich recently was published in JAMA<\/div>\n
<\/div>\n

The study was duly commented on in a management article by one of the foremost experts in the field, Professor Cliffton Callaway of Pittsburgh University.<\/span><\/p>\n

Targeted Temperature Management After Cardiac Arrest: Finding the Right Dose for Critical Care Interventions.<\/a><\/p>\n

Callaway CW. JAMA. 2017 Jul 25;318(4):334-336. doi: 10.1001\/jama.2017.8977.<\/p>\n

Callway pointed out that although the study failed to show a statistically significant 15% absolute difference in survival between the Groups, the results indicated that there could be a minor but still interesting difference in favor of the longer cooling period. This will only confirm a much larger study. Futhermore, the study was famed for both good data quality and good follow up of the patients. Survival in both study Groups was also much higher than reported in previous similar studies. This may be due to serveral factors,\u00a0\u00a0not to mention that both prehospital and hospital treatment have gereally improved over the years.<\/p>\n

<\/div>\n

The two Norwegian co-authors of the study wish to thank all involved healthcare professionals in general and the families and patients who said yes to participate in particular. They think this publication illustrates the possibilities and importance of collaboration between research groups and between institutions in several countries. That way, they hope the publication can serve as inspiration for younger colleagues.<\/span>[:]<\/p>\n","protected":false},"excerpt":{"rendered":"

[:no]NY INTERNASJONAL STUDIE VISER AT LENGRE NEDKJ\u00d8LING ETTER HJERTESTANS IKKE GIR SIKKER BEDRING AV PROGNOSEN Stavanger universitetssjukehus har som eneste norske sykehus deltatt i en europeisk hjertestansstudie som nylig ble publisert i Journal of the American Medical Association (JAMA). Selv…<\/p>\n

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