Category Archives: 2019

How can you increase innovation in your lab? How can you combine being a scientist and a health innovator?

These are some of the topics that will be discussed at the innovation intro course for professors to be held in Trondheim at the end of this month. The School of Health Innovation is a collaborate initiative between UIO, NTNU and Karolinska Institute aiming to provide life science researchers and clinicians with tools and insight into how innovation can be put to work for the benefit of patients, the healthcare system and our society. The course was initiated in 2017 delivering courses to life science PhDs, post-docs and clinicians from Nordic universities. There is no course fee, and lunch/dinner is covered by the School of Health Innovation. Participants cover expenses for accommodation and travel. There are only 20 slots available for this course, so please sign up! If you are interested please register by 15 November, by sending your CV to Bjarte Reve, project manager for School of Health Innovation (HIS) bjarte.reve@medisin.uio.no

Program – School of Health innovation for professors(pdf)
Learning outcomes
After completion of the course the participants will be able to:

  • Demonstrate an understanding of the opportunities of health innovation and entrepreneurship for utilization of research
  • Increase innovation and productivity in your lab/research group
  • Utilize incentives in order to increase innovation in your lab/department
  • Apply scientific background and knowledge of health innovation to address challenges and develop services and products within a clinical setting and a biopharma/medtech setting
  • Use various business tools for ideation and feasibility studies; to develop, prototype and test solutions to user needs
  • Demonstrate an understanding of how the Tech Transfer Office and other innovation support actors can support the commercialization process
  • Apply the basics in financing a startup company from private and governmental funding bodies
  • Assess their skills in health innovation and reflect on the exploitation of their own research
  • Combine being a scientist and a health innovator/entrepreneur

When & where
Dates: 28-29 November 2019.
Venue:Det Kongelige Norske Vitenskapers Selskap, Elvegata 17,Trondheim
Hotel for participants: Quality Hotel Augustin

(Norwegian) Forskningsenhet for helseundersøkelser (FHU)

Forskningsenhet for helseundersøkelser (FHU) er en kjernefasilitet ved Universitetet i Bergen. FHU er et samarbeid mellom Det medisinske fakultetet (MF) og Haukeland universitetssykehus (HUS) og administrativt underlagt Klinisk institutt 2 (K2). FHU er etablert med økonomisk støtte fra Trond Mohn stiftelse (TMS).

FHU bistår forskningsgrupper innen ulike fagmiljøer og kan drive både observasjonsstudier, intervensjonsstudier, befolkningsstudier, longitudinelle studier, samt barnestudier. Studier utføres på friske personer og pasienter med lettere sykdomstilstander som ikke krever sykehusinfrastruktur.

Se video om FHU her.

 

PhD defense – Christel Gill Haanshuus

Christel Gill Haanshuus will defend her PhD thesis on Tuesday 12th November 2019

Trial lecture: Tuesday 12th November 2019 at 10.15.
Topic: “Diagnostikk av malaria: Metodologiske aspekter hos reisende og i endemiske områder”
Place: Auditorium 4, BB-bygget, Jonas Lies vei 91

Public defense: Tuesday 12th November 2019 at 12.15.
Title of dissertation:“PCR based Malaria diagnostics – Method development and application”
Place: Auditorium 4, BB-bygget, Jonas Lies vei 91

1st opponent: Associate Professor Michael Alifrangis, University of Copenhagen, Denmark
2nd opponent: Professor Anna Farnert, Karolinska Institute, Sweden
3rd member of the comittee: Professor emerita Birgitta Åsjø, Universitetet i Bergen

The defense will be led by professor Ola Myklebost.

New publications

Here are recent publications with contributions from K2 based on last week’s search on PubMed (and optionally articles that have not been included in previous lists). This time the list includes in total 15 recent publications. The entries appear in the order they were received from NCBI. If you have publications that are not included in this or previous lists, please send the references to Hege F. Berg.

Continue reading

A little more about the Nobel Prize in Medicine or Physiology 2019

This year’s Nobel Prize in Medicine or Physiology was awarded to William G. Kaelin Jr., Sir Peter J. Ratcliffe and Gregg L. Semenza for the discovery of how cells sense oxygen and adapt their metabolism to different oxygen levels. Their findings are of great clinical relevance and explain, among other things, how erythrocyte formation is regulated and the mechanism for the development of various cancers as also discussed in the K2-editorial in Week 42.

I think it is interesting that all the three award winners are clinicians and have approached the problem of oxygen sensing from different angles. The paediatrician Semenza and the nephrologist Ratcliffe studied erythropoietin regulation, while oncologist Kaelin’s approach was to understand a rare tumour syndrome characterized by stress hormone-producing tumours in the adrenal medulla (phaeochromocytoma), angioblastomas in the central nervous system, and multifocal renal cancer (von Hippel Lindau’s syndrome (VHL)). He found that the VHL protein forms a complex with hypoxia-inducible factor 1-alpha (HIF1a) that leads to degradation of HIF1a. Lack of VHL generates a hypoxic signal eventually leading to angiogenesis and tumour formation.

What can we learn from them? Perhaps one message is that it is difficult to predict where the next major medical breakthrough will come from, and that too much ear marking of research resources in specific directions (read research programs) is less fruitful than letting scientists choose their own problems to study. As one research leader put it: “We don’t care what you do; we want you to be one of the leaders in your field”. Another tenet is the power of translational research in which studies of rare monogenic diseases can lead to breakthroughs in the understanding of basic physiological mechanisms that, in turn, open up to the development of new exciting therapies.

Let this year’s Nobel Prize be an inspiration for good translational research

Eystein

(Norwegian) Forespørsel om tema for bacheloroppgaver i human ernæring

Kjære kollegaer og stipendiater,

Våren 2020 skal studenter på bachelorprogrammet i human ernæring skrive en bacheloroppgave. Oppgaven skal utgjøre 15 studiepoeng, som tilsvarer ca. 6 uker fulltidsarbeid. Målet med oppgaven er å gi studentene erfaring med ernæringsvitenskapelig arbeid, i form av planlegging, gjennomføring og presentasjon av et vitenskapelig prosjekt. Oppgaven kan være en begrenset empirisk oppgave eller en litteraturoppgave (review). Litteraturoppgaver er anbefalt, og den skal helst være en ‘systematisk review’. Studentene får opplæring i litteratursøk og skriveteknikk som en del av emnet. Veiledningen vil i hovedsak fokusere på vitenskapelig innhold. Erfaringer fra i fjor viste at det er lurt å finne et begrenset tema med ukontroversiell litteratur.

I den forbindelse ønsker Programutvalg i ernæring forslag til ernæringsrelaterte temaer for bacheloroppgaver. Studentene begynner på oppgaven i januar 2020. Innlevering av oppgaven er fastsatt til tidlig i mai, og muntlig eksamen (inntil 30 minutt med presentasjon og diskusjon) skal holdes i slutten av mai.

Emnebeskrivelse for bacheloroppgaven finner dere her.

Programutvalget ber om en kort beskrivelse (max. 1/2 side) av aktuell(e) bacheloroppgave(r) innen 4. januar. Bruk gjerne denne malen og send den på e-post til sigrun.stefnisdottir@uib.no

Oppgavene vil bli presentert for studentene på et møte tidlig i januar 2020. Det er ønskelig at veileder er tilstede på presentasjonen.

Informasjon om bachelorprogrammet finner dere på web her.

Hilsen Programutvalget i ernæring

(Norwegian) Forespørsel om tema for masteroppgaver i klinisk og human ernæring

I forbindelse med at studentene på masterprogrammene i klinisk og human ernæring skal skrive en masteroppgave, etterlyser Programutvalget for ernæring nye masteroppgaver i ernæring. Masteroppgaven skal gi 60 studiepoeng og er beregnet til to semester fulltidsstudium. Studentene velger oppgave innen april 2020, og arbeidet med oppgaven blir høsten 2020 – våren 2021. Studentene skal få oppnevnt maks to veiledere i forbindelse med arbeidet med masteroppgaven. Enten hoved- eller biveileder må være tilsatt ved Universitetet i Bergen.

Programutvalget ber om en kort beskrivelse (max. 1 side) av forskergruppe og aktuell(e) masteroppgave(r) så snart som mulig. Bruk gjerne denne malen og send på e-post til sigrun.stefnisdottir@uib.no. Oppgavene vil bli presentert for studentene på et møte 21. november, kl. 13-16. De som har sendt inn oppgaver tidligere år, men fortsatt ønsker studenter i tilknytning til prosjektet, bes sende inn oppgavene på nytt.

Programutvalget nedsetter en komité som skal godkjenne alle tema før de presenteres for studentene. Dersom oppgaven er av klinisk karakter bør det være en kliniker som er veileder. Det tillates normalt maks to studenter tilknyttet et prosjekt. Emnebeskrivelsen for masteroppgaven i de to masterprogrammene finnes her:
http://www.uib.no/emne/NUCLI395
http://www.uib.no/emne/NUHUM395

Vennligst spre forespørselen til aktuelle ved din avdeling/institusjon. Ta kontakt med leder for programutvalget, Jutta Dierkes: jutta.dierkes@uib.no eller Sigrun Stefnisdottir: sigrun.stefnisdottir@uib.no dersom dere har spørsmål.

Hilsen Siri

CCBIO Junior Scientist Symposium November 7th

We have the pleasure of inviting you to our CCBIO Junior Scientist Symposium (JUSS) November 7th, 2019!
The keynote speaker, Carina Strell from Karolinska Intitutet, Sweden, will present how the microenvironment affects cancer progression and treatment response. In addition, we will hear interesting studies from local junior researchers. Join us for a perfect occasion for professional input and networking!
Open for all and free, including lunch.
When: November 7th 2019 10.00-14:00
Where: Conference room, BB-building (across the hall from the auditoria)
Program: can be found in this poster
Registration: At ccbiojuss.no Registration deadline: November 5th at noon.
Postdocs Kenneth Finne and Cornelia Schuster are chairs and can be contacted for questions.

MSD Lunch and Learn Seminar Invitation November 7th

Learn about the Mesoscale multiplex immunoassay platform. The platform offers solutions ranging from validated assays for research & clinical biomarkers to open platform assays allowing you to create your own multiplex/singleplex assays in Human, Rodent and NHP.

Date: Thursday, November 7th, 2019
Time: 11:30-12.30
Location: Seminar room 5.1/5.2, Laboratory building, 5th floor

Registration not needed – but if you sign up, no later than November 5th, we will provide a sandwich.
Registration: Janne Pleidrup Andersen

More information here.

Invitation to Single Cell and Spatial Transcriptomics Scientific Seminar November 19th

The Core facility for flow cytometry has received a 10x Chromium Controller instrument for single cell sequencing. The instrument is available for use through their booking system. In conjunction with the purchase, 10x will host a scientific seminar for researchers with an interest in single cell Gene Expression analysis and spatial transcriptomics.

Single cell sequencing has revolutionized life science research leading to a deeper understanding of biological processes in health and disease. Rapid technology advances are enabling large-scale projects for resolving single cell populations from 100s to millions of cells in a given study.

In this seminar we will introduce a combined workflow with optimized sample preparation and demonstrate a variety of single cell applications.

For registration and more information, visit https://www.eventbrite.com/e/single-cell-and-spatial-transcriptomics-scientific-seminar-bergen-norway-registration-77985951079

Date and Time
Auditorium 4, BB-building
Tue, November 19, 2019
10:00 AM – 12:30 PM

New publications

Here are recent publications with contributions from K2 based on last week’s search on PubMed (and optionally articles that have not been included in previous lists). This time the list includes in total 17 recent publications. The entries appear in the order they were received from NCBI. If you have publications that are not included in this or previous lists, please send the references to Hege F. Berg.

Continue reading

The OWLS prepare for landing…

It is hard to keep track regarding the variety of teaching and teachers affiliated with K2 and participating in the range of University initiated subjects within the programs of dentistry, medicine, nutrition and pharmacy. Each program are using teachers across departments. With K2’s organizational structure the Research group leaders are those formally “in line” but their main focus are regarding the group/participants’ research. To fully be aware of each of their group members’ participation and competence regarding teaching may not be on top of the leadership agenda.

K2 therefore has initiated a process to bring forward the teaching responsibilities we hold at our department and propose the function called UGLE (OWL); Norwegian UndervisningsGruppeLEder (Group leader for teaching/education). The UGLE should hold a permanent academic position and within the specified subject allocated, surveil all the teachers at K2 within this subject, across research groups.

The working group has proposed a mandate and suggested who will be honored with the first 2-year round of being an UGLE. We have also named their vice-UGLE who should step up during UGLE-absence and as UGLE for the following period.

I would ask all of You teachers to look through the mandate; are the functions amended to the UGLEs appropriate?  Are there teaching areas/subjects that we are unaware of? Do You find which UGLE cover your teaching area(s)? The working group really need Your feedback to correct the mandate before we release the UGLEs.

Another matter: as mentioned in K2-nytt before summer break: K2 will prioritize bioinformatics. We thus embark on a survey regarding what You as academics consider needed to be provided of bioinformatics education. Anagha Joshi (the K2 affiliated bioinformatician) will submit at questionnaire to the academic staff. I hope most of you will provide answers: WHAT are Your needs? Hopefully then we may tailor the bioinformatics education to the different needs within K2.

HSE-corner: Safety inspection rounds 2019

Preparations for this year’s safety inspection rounds are ongoing! The safety representatives and head of administration will go through the physical work environment at Laboratoriebygget on Monday 4th November and BUS and Kvinneklinikken on Wednesday 27th of November.

We kindly ask everyone who has anything to report, to fill out and send in the forms to Julie by email (select the form that fits you). Deadline for sending in the forms is the last Friday prior to the safety rounds, specifically Friday 1st November for Laboratoriebygget and Friday 22nd November for the round on BUS and KK. Please do not hesitate to get in touch if you have any questions. More information and the forms are available on the following website.

K2 congratulates Eystein Husebye on Helse Vest’s Research award 2019.

Helse Vest’s 2019 Research award was awarded Eystein Husebye. Head of department Pål Njølstad received the award on behalf of Eystein, who himself was away when the award was announced during the 2019 Helse Vest research conference this Thursday. Congratulations!

Read the article on the reward here (norwegian).

From left CEO Eivind Hansen, Helse Bergen, Pål Njølstad, UiB (on behalf of the research award winner Eystein Sverre Husebye), og technical director Helse Vest, Baard-Christian Schem. Photo: Silje Katrine Robinson.

Hands-on proposal writing seminar

Research advisors at the Faculty of Medicine invite you to join us during this hour where we will show examples of successful proposals focusing on the introduction, objectives and various forms of impact. We will show examples of the difference between communication and dissemination and present upcoming deadlines. The department serves lunch so we would appreciate if you can register. Registration deadline is 5 November.

Time: 7 November at 12.00-13.00
Venue: Seminar room 7.1 and 7.2

Pasteurlegatet & Thjøtta’s legat

Pasteurlegatet and Professor Th. Thjøttas legat will award a grant on the 27th of December this year to young Norwegian scientists who intends to study a topic regarding infectious agents, chemistry or fermentation industry.

The grant is preferably given to young, active and promising researchers, under the doctoral level. Emphasis is placed on documentation of preliminary results and evaluations of their efforts. Priority is given to specific operational and equipment-related needs, rather than traveling, accommodation, general study support and publication expenses.

It is usually not granted support more than twice to the same person. However there is the possibility of exceptions in special cases.

Any award will ordinarily not exceed 15.000, – NOK.

The application must include a short project description with a budget (up to 3 pages) and curriculum vitae (maximum 2 pages).

The application should be submitted by December 1, 2019 to Pasteurlegatet’s secretary Mari Støen, Department of Microbiology, University of Oslo, Oslo University Hospital to email:mari.stoen@medisin.uio.no

See also Pasteurlegatet’s website.

PhD defense – Shahinul Islam

Shahinul Islam will defend her PhD thesis on Tuesday 05th November 2019

Trial lecture: Tuesday 05th November 2019 at 14.30.
Topic: “The role of non-neutralizing antibodies in protection from influenza”
Place: Auditorium 4, BB-bygget, Jonas Lies vei 91

Public defense: Wednesday 06th November 2019 at 10.15.
Title of dissertation: “Live Attenuated Influenza Vaccine (LAIV) Immunization in Children and Adults: Lesson for Development of Universal Influenza Vaccine”
Place:  Auditorium, AHH, Haukelandsveien 28

1st opponent: Professor Anke Huckriede, University of Groningen, the Netherlands
2nd opponent: Researcher Craig Morton, Havforskningsinstituttet
3rd member of the comittee: Professor Silke Appel, Universitetet i Bergen

The defense will be led by professor Einar Thorsen.

New name

My name is Jonelle Dickow Villar and I am delighted to join the wonderful group of people at K2. My professional experience in Norway has focused on psychiatric nursing.  Last year I was fortunate to complete my master’s degree in the Epigenetics and Multiomics group with Stéphanie Le Hellard and the Martins group with Vidar Steen.  On July 1st this year I returned as a PhD student and will be continuing the work on identifying epigenetic modifications following different environmental exposures, including the antipsychotic drug olanzapine. You can find me on the 2nd floor or by email Jonelle.Villar@uib.no